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Abbreviations ACSL4 Acyl-CoA Synthetase Long Chain Family Member 4 ASK1 Apoptosis Signal-Regulating Kinase 1 Bak Bcl-2 Antagonist Killer Bax Bcl-2-Associated X Protein Bcl-2 B-cell lymphoma 2 BSEP Bile Salt Export Pump Caspase-1 Cysteinyl Aspartate Specific Proteinase 1 CoQ10 Coenzyme Q10 CVDs Cardiovascular Diseases CYP3A4 Cytochrome P450 3A4 FXR Farnesoid X Receptor GSH Reduced glutathione HIF-1α Hypoxia-Inducible Factor 1 Alpha HMG-CoA 3-Hydroxy-3-Methyl-Glutaryl-Coenzyme A JNK c-Jun N-terminal Kinase LDL Low-Density Lipoprotein LPS Lipopolysaccharides MAPK Mitogen-Activated Protein Kinase MRP Multidrug Resistance-Associated Protein MAFLD Metabolic Dysfunction–Associated Fatty Liver Disease MASH Metabolic Dysfunction–Associated Steatohepatitis NF-κB Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells NLRP3 NOD-Like Receptor Family Pyrin Domain Containing 3 NTCP Sodium-Taurocholate Cotransporting Polypeptide OATP1B1 Organic Anion Transporting Polypeptide 1B1 PARP Poly (ADP-ribose) Polymerase SIRT1 Sirtuin 1 SLCO1B1 Solute Carrier Organic Anion Transporter Family Member 1B1 SOD2 Superoxide Dismutase 2 SULT2A1 Sulfotransferase Family 2 A Member 1 TGF-β Transforming Growth Factor Beta TLR4 Toll-Like Receptor 4 UDPGT1A1 UDP-Glucuronosyltransferase 1A1 VEGF Vascular Endothelial Growth Factor Author contributions Conceptualization and Design of the Study: WME, MAA