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This study clearly demonstrated that tanshinone IIA exerts its protective effects by inhibiting cellular death caused by oxidative stress, but the molecular target of its direct action remains unclear

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As early as 1989, Murphy's group discovered that glutamate caused neuronal cell death by inhibiting system x c - (Murphy et al., 1989), which was later named “oxytosis” by Maher's group in 2001 (Tan et al., 2001)