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Treatments for Crohn’s Disease Traditional treatment for IBD typically requires a wide variety of pharmaceutical medications, ranging from: Corticosteroids & Prednisone Biologic therapies Antibiotics Immunosuppressive medications Patients with a chronic condition or a severe diagnosis may require surgery to remove the large intestine, resulting in a lifelong need for a colostomy bag, which is an external or internal plastic pouch for fecal and waste removal