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It is tempting to speculate that as tumor cells reprogram metabolism in response to microenvironment conditions, there may be co-evolution of γ-glutamyl cycle enzyme adaptations that optimally select with, or reciprocally to, the other central metabolic pathways

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Unfortunately, if your body is not methylating efficiently, due to a genetic mutation in the MTHFR gene, disease, chronic stress, or nutritional deficiency, you are likely not only lacking L-methylfolate, but also L-glutathione