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A defining feature of the entire DSIP literature, from the original 1978 studies through to more recent animal work, is very small sample sizes — the foundational human sleep trials involved six to ten participants in total
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Beside a direct anti-inflammatory effect on infiltrating immune cells and resident glial cells, cortistatin may also avoid the infiltration of macrophages and neutrophils to the inflamed nerve by decreasing the release of a chemokine, such as CCL2, that is critically involved in the progression of neuropathic pain [59]
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