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Another group reiterated the importance of this pathway in mouse and human salivary gland cell cultures, with p53-mediated apoptosis being reduced in mice treated with keratinocyte growth factor-1 (KGF-1) 1 h prior to and immediately following 15 Gy IR, which correlated with improved salivary gland function and increased amylase content of saliva at 16 weeks post-IR [75]