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As discussed above, boswellic acids—particularly AKBA—suppress NF-κB activation by inhibiting the phosphorylation of IκBα, thereby preventing NF-κB nuclear translocation
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The former work by exerting high GSTπ-inhibitory activity, while the latter comprise inactive compounds designed to target tumor tissue locally by undergoing GSTπ catalysis in the tumor to release cytotoxic metabolites
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