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A 2020 review in Molecules highlighted this risk explicitly, noting that compounds promoting angiogenesis could theoretically support tumor vasculature (PubMed PMID 32630751)

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Changes in BBB integrity, endothelial receptor and transporter function, vascular dysfunction, amyloid burden, and neuroinflammatory status can influence nanoparticle penetration, biodistribution, cellular uptake, and target engagement (Haqqani et al., 2024)

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