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Human Rele-Vance) Classical MPTP and 6-hydroxydopamine (6-OHDA) toxin paradigms, invaluable for dissecting basal-ganglia circuitry, nonetheless model an acute, region-restricted chemical lesion rather than the slow, multisystem decline typical of idiopathic PD [282,283,284]

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However, most studies of hyperferritinemia do not use this correction, which is mainly used to evaluate patients with a suspected iron deficiency