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In Vivo Kratom extract, tea, and purified alkaloids including mitragynine, 7-hydroxymitragynine, speciociliatine, mitraciliatine, isopaynantheine, corynanthidine, and corynoxeine have shown robust antinociceptive effects in rodents using the hot plate and/or tail-flick assays (Matsumoto et al., 1996a,b
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