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Therefore, a systematic rigorous chemical kinetics approach, which is routinely used in investigations of small molecule reactions, is becoming available to study more complicated enzymatic systems, which is expected to allow a deeper insight into cellular functions
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In conclusion, RGSH intervention can down-regulate the renal ACSL4 mRNA expression level and up-regulate the GPX4 mRNA expression level in the development of AKI, and reduce the lipid oxide and iron ion levels, thereby reducing iron accumulation, alleviating cell damage and ameliorating intraoperative AKI by inhibiting ferroptosis