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Clinically, in vitro studies have demonstrated that Acinetobacter calcoaceticus impairs regulatory T cell (Treg) differentiation and enhances the differentiation of T helper cells (Th1 and Th2)
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In rodent models, prolonged or binge alcohol exposure activates nuclear factor kappa-B (NF-KB) pathways and increases lipid peroxides, nitrite levels, NADPH oxidase (NOX), cytochrome c oxidase II, and reactive O 2 - and O 2 - derived oxidants in brain [74-76]
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