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Preclinical rodent studies showed reductions in body fat mass at doses roughly equivalent to 500 mcg in a 70 kg human, with the effect appearing dose-dependent up to a plateau

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The tesofensine plus 5-HTP/CB combination does not result in synergistic interaction in a sucrose intake suppression assay The anorexigenic effects of tesofensine, 5-HTP/CB and 1:1 and 3:1 combinations of individual components were assayed by the consumption of sucrose