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Potential implications of the new pharmacotherapies on obesity management The mean WL in clinical trials with the most efficacious new obesity pharmacotherapies ranges between 15% and 25% at 1 year (and it may be even higher for some agents that have not reached weight plateau at study completion)

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The idea behind CagriSema is straightforward: semaglutide alone produces significant weight loss (typically 15 to 17 percent), but adding cagrilintide targets a second appetite regulation pathway through the amylin system