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Sources: Harvard Health, Cleveland Clinic Sources: Harvard Health, Cleveland Clinic Sources: National Library of Medicine, American Journal of Preventative Medicine The above statements are sourced from scientific studies and have not been evaluated by the Food and Drug Administration
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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 μg vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy