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40 The anti-adipogenic effects of AMPK are mediated by suppressing PPARγ via positive regulation of p38 MAPK, which promotes PPAR phosphorylation and inhibits its transcriptional activity

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Symptoms of vitamin B12 deficiency include (1): chronic fatigue shortness of breath heart palpitations tingling or numbness in the extremities poor balance loss of concentration poor memory disorientation mood changes incontinence insomnia People most at risk of developing a deficiency include older adults, as well as those who smoke, abuse alcohol, or follow a vegetarian or vegan diet