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Toxicities can occur from exposure to heavy metals (mainly lead and mercury), contrast agents, and some chemotherapeutic agents (anthracyclines, bleomycin, and cisplatin) [234,235,236]
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Importantly, non-productive HSV-1 infections can also lead to the expression of cytokines and pro-inflammatory molecules, such as interleukin-1β (IL-1β), TNF- α , IL-6, IL-8, macrophage inflammatory protein 1 α (MIP-1 α ), chemokine (C-C motif) ligand 5 (CCL5) and chemokine CXCL10 in human microglial cells (Lokensgard et al., 2001)
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