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In addition, glycoside compounds such as baicalin, vitexin, and forsythoside A (Table 2) can also improve hepatic fibrosis by inhibiting the body’s OS, regulating intestinal flora bile acid metabolism, increasing antioxidant and phase II detoxification enzyme activity

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CYP3A4 mediated N-demethylation to nor hydrocodone is the primary metabolic pathway of hydrocodone with a lower contribution from CYP2D6 mediated O-demethylation to hydromorphone