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Because these pathways are relevant to vascular biology and connective tissue systems, BPC-157 has been studied across a range of experimental tissue models, including gastrointestinal, musculoskeletal, vascular, and neural systems

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It also immediately triggered the internalization of VEGFR2 and subsequently activated the phosphorylation of VEGFR2 and Akt, and the eNOS signaling pathway without the need for other known ligands or shear stress[107]