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As an alternative or additional function, we propose that the targeting of LRP6 to AP2-containing structures assists assembly of a signalosome by exposing its components to kinases that are co-targeted to these locales by AP2, and that these kinases could remodel the structure or activity of the signalosome by phosphorylating its components (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Awasthi S., Cheng J., Singhal S.S., Saini M.K., Pandya U., Pikula S., Bandorowicz-Pikula J., Singh S.V., Zimniak P., Awasthi Y.C