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Collectively, these factors make catalytic antioxidants with H 2 O 2 -scavenging activities good candidates for several acute and chronic neuronal disorders that involve the overproduction of ROS such as PD [87], Huntington’s disease (HD) [88], Alzheimer’s disease (AD) [89], ALS [90], stroke [91], and trauma [92]
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Our study has important implications for our understanding of enzymatically active and inactive glutaredoxins and could be useful for the design and optimization of artificial glutaredoxins, glutaredoxin-coupled fluorescent redox sensors and transition-state inhibitors
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