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subtilis was found to further exhibit anti-aggregation properties by regulating the sphingolipid metabolic pathway involving upregulation of LAGR-1/CERS1 (ceramide synthase), ASM-3/SMPD1 (acid sphingomyelinase), and downregulation of SPTL-3/SPTLC2 (serine palmitoyltransferase), therefore, reducing glucosylceramide ( In PD and AD individuals, an increased abundance of Enterobacteriaceae taxa, particularly Escherichia coli , is associated with increased concentrations of LPS and the bacterial amyloid protein curli (Scheperjans et al., 2015