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Carboxylic acid–based pY mimetics, such as carboxymethylphenylalanine (cmF) and carboxyphenylalanine (cF), have demonstrated promising binding to Grb7-SH2 under physiological conditions (Figure )

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Thus, supplementation of SAMe, 5-MTHF, and B12 promotes the methylation process to help the body eliminate estrogens and avoid the conversion of 4-OH-E1 into reactive quinones and semiquinones