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Affinity maturation of antibody R023 Cryo-EM-enabled structural characterization of R023 binding to sotorasib-conjugated p*MHCs revealed that R023 recognizes primarily the HLA and hapten moieties of its antigens, with mutational data confirming the central role of the hapten in antibody binding 33

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Keratinocytes displace the sebocytes and the resulting loss of sebum affects the skin’s ability to promote beneficial bacterial colonization [7] [20] and prevent scale from building up within the follicular canal