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890,891 It is still unclear, however, whether disulfide bond alterations contribute to activation in vivo under physiologic or pathologic conditions
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In the OR51E2 structure, the conserved FYGx 6.50 motif in TM6 substituted the canonical CWxP motif, forming an extended hydrogen-bonding network between the residues of Y 6.48 , S 3.40 , R 4.52 and D 5.50 that leads to the outward movement of TM6 in the cytoplasmic end, similar to the arrangement of the canonical PIF motif