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To address this possibility, in a number of animal 118,119 and human studies, 120 high doses of anti-catabolic glucocorticoids, which inhibit the activation of MMPs 121 and the expression inflammatory cytokines, 122 have been administered

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On dermoscopy, after 3 months of treatment, some improvement was noted on right side in the form of decreased shades of pigmentary network in cases of epidermal melasma and decreased irregularity of pigmentary network, decreased number of granules and globules in cases of mixed melasma in comparison with baseline