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These formularies vary by plan somewhat, but tier 1 is typically reserved for generic drugs, while brand-name, nonpreferred, and specialty drugs occupy the higher tiers

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IL-1β increases in a manner dependent on NLRP3 activation.[ref] Airborne trichothecenes/aflatoxin G1 → NLRP3 activation → IL‑1β and other cytokines → airway inflammation Aflatoxin G1 airborne exposure significantly increases inflammation in the lung