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found that synovial NK cells co-cultured with monocytes can induce and promote the differentiation of monocyte lineages into osteoclasts, leading to bone and joint damage ( 3 Treatment of RA Traditional drug DMARDs including cyclophosphamide, sulfasalazine, methotrexate and NSAIDs are commonly used in the treatment of RA, although they can lead to some side effects and other functional impairments
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