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corpus callosum in CAE), in the former, a deliberately orchestrated primary autoimmune process directed at myelin antigens results in lymphocytic infiltration, secondary injury to white matter and a universal innate response, whereas in CAE, where the primary insult is a biochemical one deliberately targeting intrinsic CNS myelin, following immune stimulation, the resulting lesion is pathologically similar ( a priori knowledge of what insults were applied, and in which order, simply observing the final histological lesion renders it impossible to infer the underlying sequence of events nor the initial trigger