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Differentiating from Other Conditions Neurological signs and symptoms can be vitamin B12 deficiency associated or due to other causes such as: Pernicious anemia Syphilis Neurosyphilis Human immunodeficiency virus (HIV)-associated vacuolar myelopathy Toxic neuropathies Tropical myeloneuropathy Your healthcare provider can make a proper diagnosis based on your symptoms, medical history, physical exam, and laboratory test findings