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Medications (Prescribed if needed) H1 blockers (examples: loratadine, cetirizine, fexofenadine) – help with itching, flushing, hives H2 blockers (example: famotidine) – support digestion and reduce stomach-related symptoms Mast cell stabilizers (examples: cromolyn sodium, ketotifen) – calm the immune system Leukotriene inhibitors (example: montelukast) – help with breathing or inflammation Epinephrine auto-injector – prescribed if there is a risk of severe allergic reactions Older sedating antihistamines such as diphenhydramine are avoided for long-term use
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TPL also inhibits NF-κB nuclear translocation to reduce the expression of anti-apoptotic genes such as XIAP and Survivin, while blocking pro-survival signaling pathways like PI3K-AKT and Src-ERK, collectively amplifying apoptotic effects (Li X
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