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At 3 months, 59% of the MPT group reported moderate or marked improvement compared to 26% in the GTM group – a statistically significant difference
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Thus, in individuals with GST M1 null genotypes, the activation or overexpression of GST P1-1, GST A1-1, GST A2-2, or GST A4 may potentially compensate for the secondary detrimental effects associated with this genetic deficiency
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