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23 Studies using GLT‐1 deficient mice, which express only 20% of normal GLT‐1 levels to simulate chronic GLT‐1 reduction, have shown that these mice exhibited a phenotype resembling attention‐deficit/hyperactivity disorder, including hyperactivity, impulsivity, and impaired memory
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This ADI has been criticized for being much lower than scientific evidence would indicate is warranted .²⁴ For example, it has been demonstrated that breast-fed infants consume 4.5 times more free glutamate than the EFSA’s ADI.¹³ Finally, it has been pointed out that free glutamate and glutamate salts make only a “marginal contribution” to total dietary glutamate intake.¹⁰ While not all regulatory authorities agree on whether free glutamates should be limited, human studies have shown that extremely high levels of free glutamic acid (137 g per day) can be ingested for 30 days or longer with no ill effect.²⁵ This is because our bodies are great at regulating the amount of glutamate in our blood