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To evaluate the validity of this hypothesis, spatial learning was monitored using the Morris water maze task, a hippocampal-dependent spatial learning task requiring rats to locate a pedestal hidden beneath the surface of the water by orienting to extra-maze cues
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In addition to duplication, which also seems to be a high-penetrance risk factor, five cases of a de novo deletion of 593 kb on chromosomes 16p11.2 were found among Autism Genetic Resource Exchange (AGRE) families (Weiss et al., 2008)
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