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Why mitochondria matter As you might recall from your high school biology textbook, mitochondria are considered the powerhouses of the cell because of their role as energy suppliers, intercellular signalers, and metabolic coordinators.3 As such, they’re central to a biological process called apoptosis (cell death), which involves the disposal of damaged or abnormal cells.4 Also, apart from the nucleus, mitochondria are the only other parts of a human cell that carry DNA.5 Therefore, mitochondrial dysfunction is inextricably linked to health conditions stemming from cellular breakdown and chromosomal changes, both of which correlate with aging.6 7 Apart from primary mitochondrial diseases such as Leigh syndrome and MELAS syndrome, these health conditions include but aren’t limited to:8 9 10 Cancer Diabetes Heart disease Kidney diseases Neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s) Hearing loss Eyesight abnormalities Oxidative stress Metabolic imbalance Inflammation Myalgic encephalomyelitis, or ME/CFS (potentially