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In comparison with the general population, SLE patients have a higher frequency of vitamin D deficiency due to their avoidance of sunlight to prevent flares [16]

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The pathology of MS lesions is heterogeneous (Lucchinetti et al., 2000) and several patterns suggesting predominant immune-mediated inflammation (pattern I and II) and primary oligodendrogliopathy (pattern III and IV) have been described (Lucchinetti et al., 1996, 2000)