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For acute tendon healing, increased vascularization of the injured tendon is considered crucial because VEGF promotes angiogenesis and increases vascular permeability as an endogenous stimulator ( However, for chronic tendon disease, vascularization is thought to be directly negatively correlated to biomechanical properties of tendons as a persistent high expression of VEGF could induce sustained ECM degeneration by stimulation of MMPs and inhibition of TIMPs