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Accidental injection of high dose (1:1,000) epinephrine contained in epinephrine autoinjectors into fingers or thumb can produce prolonged tissue ischemia, reperfusion pain, and in some cases traumatic nerve injury (neuropraxia) lasting as long as 8-10 weeks (Fitzcharles-Bowe et al, 2007

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however, after several months of feeding LD containing 4% EtOH, acute administration of EtOH did not decrease or increased its activity [134]