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The exact mechanism of bone cancer pain remains unknown, but some studies demonstrated that neuroinflammation, glial activation in the spinal dorsal horn (SDH), and abnormal function of the NOD-like receptor protein 3 (NLRP3) inflammasomes participate in bone pain development [31]
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[DOI] [PMC free article] [PubMed] [Google Scholar] Lombardi L., Shi Y
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