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Because FOXO4-DRI’s mechanism depends on disrupting the FOXO4–p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population — leaving FOXO4-low non-senescent cells largely unaffected

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Little research has yet been conducted on epitalon by researchers without ties to Russian institutions, so it may be too soon to make definitive statements about epitalon, but the findings so far certainly give a justification for further investigation