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Indeed, during the apoptosis induced by cytotoxic agents, which by themselves induce oxidative stress such as pro-oxidants, xenobiotics, mitochondrial toxins, chemotherapeutics, and metals, GSH depletion is mediated by its oxidation to GSSG by ROS/RNS (61, 104, 169, 199, 237) (Table 1 and Fig

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Their influence on human fertility appears largely indirect , mediated by correction of metabolic disturbances that impair reproductive physiology