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These include inhibition strategies of NAD + consuming enzymes, such as CD38 and PARPs, or modulation of key NAD + synthesis proteins such as NAPRT and NAMPT, as summarized below and in Fig

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A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed