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The recombinant SmGAME36 enzyme did not metabolize hydroxylated SGAs (SlGAME31 assay products) to generate the corresponding acetylated SGA derivatives

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How PTD-DBM Works for Hair Directly activates the Wnt/β-catenin pathway, which is suppressed by DHT in androgenetic alopecia Inhibits CXXC5 – a negative regulator of the Wnt pathway – effectively unblocking the hair growth signal Promotes the conversion of vellus hairs (thin, fine hairs) back into terminal hairs (thick, pigmented hairs) Does not directly interfere with systemic hormones, reducing the risk of sexual side effects associated with finasteride What the Research Says Research from Yonsei University in South Korea demonstrated that PTD-DBM promoted new hair growth in mice within 28 days of topical application