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Recognition of this phenomenon is important, as intramuscular injection of B 12 has been shown to rapidly reverse SACD symptoms

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These fatty acid substrates are oxidised non-enzymically by free radicals or through different enzymic pathways including the cyclo-oxygenases (COX), lipoxygenases (LOX) and cytochrome P450 pathways to produce both pro-inflammatory and resolving eicosanoids (Fig