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Annexin V-FITC (BD Bioscience, 556419), 7-AAD (eBioscience, 00-6993-50), mouse TNF-α (R&D systems, 410-MT-010), LPS (Sigma, L2630), anti-human Fas (αFas) activating antibody (Millipore, 05-201), Compound C (Sigma, P5499), PF-3644022 (Sigma, PZ0188), (5Z)-7-Oxozeaenol (Cayman, #17459), pQE-His-TRAIL was a kind gift from SH Kim (Korea National Cancer Center) and was used for the purification of His-tagged human TRAIL and for the cell and in vivo experiments as reported previously [63]