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Notably, during the last three decades, different laboratories, including our own, underscored the pivotal role of astrocyte and microglial mediators in the parkinsonian brain, as documented in epidemiological, post-mortem, and animal studies, highlighting glia as a common final pathway directing toward neuroprotection/neurodegeneration [8,13,14,16,17,18,19,20,21,22,23,49,50,51,52,53,54,55,56,57,80,111]

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They may also limit joint mobility and contribute to a loss of function, once their growth culminates with limited movement 11