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Beyond the FDA's regulatory pathway, other standards-setting organizations, such as the European Medicines Agency (EMA), ASTM International, and the International Organization for Standardization (ISO), have also published various guidelines and standards for nanotechnology, highlighting their active involvement in advancing and harmonizing regulatory frameworks in this field (Khopade and Shah, 2025)

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Phosphorylated CREB translocates to the nucleus where it binds to cAMP response elements (CREs) in DNA, upregulating transcription of the growth hormone gene and other genes involved in GH synthesis and secretion