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This concern arises from the fact that studies of hGH have shown that long-term exogenous administration, while increasing lean body mass and decreasing adipose tissue, can also cause: increased insulin resistance, diabetes, acromegaly, cancer, hypertension (high blood pressure), and edema (swelling)

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164 ShimamuraM.SatoN.OshimaK.AokiM.KurinamiH.WaguriS.et al (2004)