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Human S100A8 and S100A9 are composed of 93 and 114 amino acid residues ( Figures 1 , 2B ), respectively, and S100A9 has an isoform of 110 amino acid residues
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These studies suggest that deficiencies in GH and IGF-I contribute to a functional decline in senescent rats, whereas augmentation of GH or IGF-I improves cognitive function, increases glucose utilization throughout the brain, increases cortical vascularity, and ameliorates age-related decline in hippocampal neurogenesis
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