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Finally, in a middle cerebral artery occlusion model of stroke, GSH-coated PLGA–PEG NPs containing the thyroid T3 hormone showed better therapeutic efficacy than T3 solution or uncoated NPs, on both tissue infarction (reduction of 58%, 34%, and 51%, respectively) and brain edema (reduction of 75%, 59% and 68%, respectively) [155]
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